Association between length of gestation and cervical DNA methylation of PTGER2 and LINE 1-HS

Autores: Heather H Burris, Andrea A Baccarelli, Valeria Motta, Hyang-Min Byun, Allan C Just, Adriana Mercado-Garcia, Joel Schwartz, Katherine Svensson, Martha M Tellez-Rojo, and Robert O Wright.
Publicado en: Epigenetics

Worldwide, more than 1 in 10 infants is born prior to 37 weeks gestation. Preterm birthgestation can lead to increased mortality risk and poor life-long health and neurodevelopmental outcomes. Whether environmental risk factors affect preterm birth through epigenetic phenomena is largely unstudied. We sought to determine whether preterm risk factors, such as smoke exposure and education, were associated with cervical DNA methylation in the prostaglandin E receptor 2 gene (PTGER2) and a repetitive element, long interspersed nuclear element-1 Homo sapiens-specific (LINE 1-HS). Second, we aimed to determine whether mid-pregnancy DNA methylation of these regions in cervical samples could predict the length of gestation. We obtained a cervical swab between 16–19 weeks gestation from 80 women participating in a Mexico City birth cohort, used pyrosequencing to analyze DNA methylation of PTGER2 and LINE 1-HS, and examined associations with maternal covariates. We used accelerated failure time models to analyze associations of DNA methylation with the length of gestation. DNA methylation of both sequences was associated with Pap smear inflammation. LINE 1-HS methylation was associated with smoke exposure, BMI and parity. In adjusted models, gestations were 3.3 days longer (95%CI 0.6, 6.0) for each interquartile range of PTGER2 DNA methylation. Higher LINE 1-HS methylation was associated with shorter gestations (-3.3 days, 95%CI -6.5, -0.2). In conclusion, cervical DNA methylation was associated with risk factors for preterm birth and the length of gestation.

Association between length of gestation and cervical DNA methylation of PTGER2 and LINE 1-HS, Burris HH, Baccarelli AA, Motta V, Byun HM, Just AC, Mercado-Garcia A Schwartz J, Svensson K, Téllez-Rojo MM, Wright RO. Epigenetics. 2014 May 14;9(8)

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Centro de Investigación en Evaluación y Encuestas del Instituto Nacional de Salud Pública de México.
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