Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City: Distribution, temporal variability, and relationship with child attention and hyperactivity

Autores: Gamola Z. Fortenberrya, John D. Meekera,∗, Brisa N. Sánchezb, Dana Boyd Barrc,Parinya Panuwetc, David Bellingerd, Lourdes Schnaase, Maritsa Solano-Gonzálezf, Adrienne S. Ettingera,d,g, Mauricio Hernandez-Avilah, Howard Hui,Martha Maria Tellez-Rojo.
Publicado en: International Journal of Hygiene and Environmental Health

Attention Deficit Hyperactivity Disorder (ADHD) is the most commonly diagnosed andHyperactive studied cognitive and behavioral disorder in school-age children. The etiology of ADHD and ADHD-related behavior isunclear, but genetic and environmental factors, such as pesticides, have been hypothesized. The objective of this study was to investigate the relationship between in utero exposure to chlorpyrifos, chlorpyrifos-methyl, and/or 3,5,6-trichloro-2-pyridinol (TCPY) and ADHD in school-age Mexican children using TCPY as a biomarker of exposure. The temporal reliability of repeated maternal urinary TCPY concentrations across trimesters was also explored (N = 21). To explore associations with ADHD-related outcomes in children, third trimester urinary TCPY concentrations in were measured in 187 mother-child pairs froma prospective birth cohort. Child neurodevelopment in children 6–11 years of age was assessed using Conners’ Parental Rating Scales-Revised (CRS-R), Conners’ Continuous Performance Test (CPT), and Behavior Assessment System for Children-2 (BASC-2). Multivariable linear regression models were used to testrelationships for all children combined and also stratified by sex. Intraclass correlation coefficients (ICC) calculations were based on a random effects model. The ICC was 0.41 for uncorrected TCPY, and rangedfrom 0.29 to 0.32 for specific gravity-corrected TCPY. We did not observe any statistically significant associations between tertiles of maternal TCPY concentrations and ADHD-related outcomes in children. However, compared to the lowest tertile we found suggestive evidence for increased ADHD index inthe highest TCPY tertile in boys (ˇ = 5.55 points; 95% CI (−0.19, 11.3); p = 0.06) and increased attentionproblems for the middle tertile in girls (ˇ = 5.81 points; 95% CI (−0.75, 12.4); p = 0.08). Considering thecontinued widespread agricultural and possible residential use of chlorpyrifos and chlorpyrifos-methylin Mexico and the educational implications of cognitive and behavior deficits, these relationships deservefurther study.

Fortenberry GZ, Meeker JD, Sanchez BN, Barr DB, Panuwet P, Bellinger D, et al. Urinary 3,5,6-trichloro-2-pyridinol (TCPY) in pregnant women from Mexico City: Distribution, temporal variability, and relationship with child attention and hyperactivity. International Journal of Hygiene and Environmental Health. 2014;217(2-3):405-12.



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Centro de Investigación en Evaluación y Encuestas del Instituto Nacional de Salud Pública de México.
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