Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu

Autores: Heather H Burris, Joe M Braun, Hyang-Min Byun, Letizia Tarantini, Adriana Mercado, Rosalind J Wright, Lourdes Schnaas, Andrea A Baccarelli, Robert O Wright & Martha M Tellez-Rojo.
Publicado en: Epigenomics (nivel 4)

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Aim: We examined the association between birth weight and methylation in the imprinted IGF/H19 loci, the nonimprinted gene NR3C1 and repetitive element DNA (LINE-1 and Alu). Materials & methods: We collected umbilical cord venous blood from 219 infants born in Mexico City (Mexico) as part of a prospective birth cohort study and analyzed DNA methylation using pyrosequencing. Results: Birth weight was not associated with DNA methylation of the regions studied. One of the CpG dinucleotides in the IGF2 imprinting control region (ICR)1 includes a potential C–T SNP. Among individuals with an absence of methylation at this site, probably due to a paternally inherited T allele, birth weight was associated with mean methylation status of both IGF2 ICR1 and ICR2. However, this association would not have survived adjustment for multiple testing. Conclusion: While we did not detect an association between DNA methylation and birth weight, our study suggests a potential gene–epigene interaction between a T allele in the IGF2 ICR1 and methylation of ICRs of IGF2, and fetal growth.

Heather H Burris*1, Joe M Braun2, Hyang-Min Byun3, Letizia Tarantini4, Adriana Mercado5, Rosalind J Wright6, Lourdes Schnaas7, Andrea A Baccarelli3, Robert O Wright6 & Martha M Tellez-Rojo5, Association between birth weight and DNA methylation of IGF2, glucocorticoid receptor and repetitive elements LINE-1 and Alu, Epigenomics (2013) 5(3), 271–281

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Centro de Investigación en Evaluación y Encuestas del Instituto Nacional de Salud Pública de México.
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